This study presents some of the current discussions and research on the topic of science popularization from the perspective of Science, Technology, and Society (STS), based on a systematic review of the literature. The systematization focuses on 53 articles published in the last decades in four databases (Scielo, Scopus, Web of Science and DOAJ). Methodologically, the parameters and procedures of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) are used, seeking to identify issues and debates around the popularization of science and also practical investigations regarding the issue. The descriptors used in the searches took the STS approach centrally into account. The results indicate the need to develop public policies to train and encourage students and researchers to get involved in popularizing science. Furthermore, considering the epistemic role of asymmetries in scientific communication can help to overcome the shallow discussion around deficit models and the development of deliberative participatory models. There is still a need for more studies on the development of participatory communication models that emphasize social justice by valuing the diversity of knowledge, methods, and communication practices.